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  • Title: [Transport of RNA from rat liver cell nuclei in vitro. Effect of superoxide dismutase on the release of rapidly labeled RNA from isolated nuclei].
    Author: Koen IaM, Peskin AV, Baru VA, Fedorchenko VV, Zbarskiĭ IB, Konstantinov AA.
    Journal: Biokhimiia; 1978 Dec; 43(12):2124-9. PubMed ID: 743506.
    Abstract:
    Purified superoxide dismutase from beaf and rat liver cytosol was found to inhibit in vitro a release of the newly synthesized poly(A)-containing RNA from isolated hepatocyte nuclei in a cell-free system. The inhibition was concentration-dependent. Similar effect was observed with Cu2+ and coppertyrosine complex, which possess SOD-like type catalytic activity. The effectiveness of the complex and of Cu2+ however was an order smaller than that of SOD. The inhibitory effects of SOD and the two other copper-containing compounds could be abolished by potassium cyanide and reduced glutathione as far as by gomologous cytosol. Catalase failed to effect the RNA release. Although serum albumin itself did not affect release of RNA it was capable to abolish the inhibitory effects of Cu2+ and of copper-tyrosine, but not that of SOD. Possible mechanisms for the inhibitory effect of SOD on RNA transfer across the nuclear envelope are discussed.
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