These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Treatment of chronic hepatitis. A comparative study of the effect azathioprine and (+)-cyanidanol-3].
    Author: Aguilar Reina J, de la Santa López J, Cuadras Avellana CM, Kern A.
    Journal: Fortschr Med; 1978 Jan 12; 96(2):75-9. PubMed ID: 74352.
    Abstract:
    The clinical, biochemical and histological results of the treatment of 2 groups of 8 patients each with chronic hepatitis (persistent or aggressive) treated with azathioprine (100mg daily) or (+)-cyanidanol-3(1.5g daily) are compared. The duration of treatmant was 6 months, with monthly examination during this period. The clinical results were comparable in the 2 groups. Among the liver function tests, (+)-cyanidanol-3 appeared superior in the case of total bilirubin, transaminases and BSP retention and azathioprine was superior as regards reduction of gamma-globulin, IgG and IgM. These different results appear to correspond to their different mechanisms of action. The tolerance was superior in the (+)-cyanidanol-3 group, in which no side effects were observed, whereas in the azathioprine group, treatment had to be temporarily interrupted in 3 patients showing leukopenia and/or thrombocytopenia. We therefore believe that it can be asserted that treatment with (+)-cyanidanol-3 yields results similar to those obtained with azathioprine, but being a non-immunosuppressive therapy is devoid of the severe consequences produced by a decrease in immunity in day-to-day clinical practice.
    [Abstract] [Full Text] [Related] [New Search]