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  • Title: Plasma cholinesterase changes during pregnancy. Their interpretation as a cause of suxamethonium-induced apnoea.
    Author: Evans RT, Wroe JM.
    Journal: Anaesthesia; 1980 Jul 07; 35(7):651-4. PubMed ID: 7435932.
    Abstract:
    Cholinesterase activities were measured on serum from 941 pregnant women distributed evenly throughout the 40 weeks of gestation. A rapid fall has been shown to occur during the first trimester to a level which did not alter significantly during the remainder of pregnancy. Even lower values were observed in 105 patients examined during the first 7 days following delivery. Enzyme activity was used to determine the probable incidence of a prolonged reaction to suxamethonium in obstetric patients. The risk was greatest in the immediate post partum period affecting 11% of the patients investigated.
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