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  • Title: Radioimmunoassayable serum somatomedin B in normal subjects and in patients with acromegaly and pituitary dwarfism: effects of human growth hormone therapy.
    Author: Wajchenberg BL, Liberman B, Gomes EN, Pieroni RR.
    Journal: Horm Metab Res; 1980 Oct; 12(10):516-9. PubMed ID: 7439876.
    Abstract:
    We report the results obtained with a radioimmunoassay for serum somatomedin B (SmB) in 29 normal subjects, in 33 pituitary dwarfs (GHD) and 6 acromegalic patients. There were no significant differences between the basal SmB levels of the GHD and the normal subjects higher value observed in the acromegalic group (p < 0.01). After acute human growth hormone administration a parallel increase of SmB serum levels and plasma growth hormone was seen (r = 0.562; p < 0.01). Of 12 GHD subjects SmB serum levels increased only in five, after chronic hGH administration.
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