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  • Title: Activation of the alternative complement pathway by Histoplasma capsulatum.
    Author: Ratnoff WD, Pepple JM, Winkelstein JA.
    Journal: Infect Immun; 1980 Oct; 30(1):147-9. PubMed ID: 7439970.
    Abstract:
    The present study was performed to determine whether Histoplasma capsulatum (yeast phase) is able to activate the alternative complement pathway. H. capsulatum yeasts were shown to consume C3 in C4-deficient guinea pig serum. Immunoelectrophoretic conversion of alternative pathway component factor B confirmed that C3 consumption was mediated by activation of the alternative pathway. These results demonstrate that H. capsulatum is able to activate the alternative complement pathway.
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