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  • Title: Relationship between sleep deprivation and urinary MHPG levels.
    Author: Amin MM, Khalid R, Khan P.
    Journal: Int Pharmacopsychiatry; 1980; 15(2):81-5. PubMed ID: 7440097.
    Abstract:
    A 5-day study, forming the initial part of two 32-day clinical trials and involving 22 unipolar depressed inpatients, was designed to determine the relationship between response to sleep deprivation and 24-hour urinary MHPG levels. A statistically significant, positive relationship was noted between the sleep deprivation, modified total HAM-D scores and MHPG levels at postsleep deprivation, indicating that the greater the severity of depression during sleep deprivation the higher were the MHPG levels after the sleep deprivation period.
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