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  • Title: Angiofollicular and plasmacytic polyadenopathy: a pseudotumourous syndrome with dysimmunity.
    Author: Diebold J, Tulliez M, Bernadou A, Audouin J, Tricot G, Reynes M, Bilski-Pasquier G.
    Journal: J Clin Pathol; 1980 Nov; 33(11):1068-76. PubMed ID: 7440754.
    Abstract:
    Two cases are reported of an apparently distinct type of immune disorder. Beginning with mild anaemia and widespread massive lymphadenopathy, the disease progressed to a fatal autoimmune type haemolytic anaemia. Serum investigation showed polyclonal hypergamma-globulinaemia and some autoantibodies. Repeat lymph node biopsies in each case showed hyperplasia within B lymphocyte territory (follicular hyperplasia and polyclonal plasmacytosis with IgG predominance) and atrophy of T dependent areas. Dilatation of lymph sinuses, vascular proliferation, and sclerosis were striking features. This appears to be a new entity, and reasons are given for separating this disease from other pseudotumourous lymph node disorders associated with dysimmunity.
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