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  • Title: Differentiation of glomerular filter and tubular reabsorption apparatus during foetal development of the rat kidney.
    Author: Schaeverbeke J, Cheignon M.
    Journal: J Embryol Exp Morphol; 1980 Aug; 58():157-75. PubMed ID: 7441151.
    Abstract:
    Differentiation of the glomerulus and the proximal tubule was studied in the rat foetus, especially with regard to the development of the protein filtration-reabsorption apparatus. Filtration starts several days before full differentiation of the glomerulus, when the glomerular basement membrane consists of a thin lamina alongside the podocyte membrane. Endocytosis is functional fom this time but fusion between endocytic vesicles and lysosome-like bodies occurs 2 days later. Foetal urine electrophoresis shows the presence of many proteins, including high molecular weight one, this proteinuria seeming chiefly due to the immaturity of the glomerular barrier.
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