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  • Title: Acquired isolated factor X deficiency associated with systemic amyloidosis. Case report and review of literature.
    Author: Girmann G, Wilker D, Stadie H, Scheurlen PG.
    Journal: Klin Wochenschr; 1980 Sep 01; 58(17):859-62. PubMed ID: 7442086.
    Abstract:
    The demonstration of acquired isolated factor X deficiency and of a biclonal homogeneous lambda and kappa light polypeptide chain proteinuria in a patient of 49 years having an obscure hepatomegaly gave clinical evidence for the rate, amyloidosis-associated factor X deficiency, which could be proven by postmortem examination. The mechanisms by which amyloid may affect factor X levels in this case may be preferentially binding to the amyloid fibrils of lambda light chain type.
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