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  • Title: The opiate antagonist naloxone does not consistently block inhibition of spinal nociceptive transmission produced by stimulation in lateral midbrain reticular formation of the cat.
    Author: Carstens E, Zimmermann M.
    Journal: Neurosci Lett; 1980 Dec; 20(3):335-9. PubMed ID: 7443080.
    Abstract:
    Electrical stimulation in the lateral midbrain reticular formation (LRF) inhibited the responses of spinal dorsal horn neurons to noxious (50 degrees C) skin heating. Systemic administration of naloxone (0.1-2 mg/kg) had no effect on inhibition produced by LRF stimulation in 10 units, while this inhibition was partially blocked in 3 units. The results indicate that endogenous opiates are not primarily involved in mediating descending inhibition from LRF stimulation.
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