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  • Title: Evidence for a role of the locus coeruleus noradrenaline system in learning.
    Author: Ogren SO, Archer T, Ross SB.
    Journal: Neurosci Lett; 1980 Dec; 20(3):351-6. PubMed ID: 7443081.
    Abstract:
    The effect of the new noradrenaline (NA) neurotoxin, DSP4, on the acquisition of one-way and two-way active avoidance responses was studied in rats. This treatment caused a marked degeneration of the locus coeruleus NA system and markedly impaired both one- and two-way avoidance acquisition. Both effects were blocked by pretreatment with desipramine, a NA uptake blocking agent. The present findings support the hypothesis that the locus coeruleus NA system in its entire extent may play a role in aversive learning.
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