These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Differential effects of imipramine in rats as a function of DRL schedule value.
    Author: McGuire PS, Seiden LS.
    Journal: Pharmacol Biochem Behav; 1980 Nov; 13(5):691-4. PubMed ID: 7443738.
    Abstract:
    Imipramine, a tricyclic anti-depressant, has selective effects on differential-reinforcement-of-low-response-rate (DRL) schedule performance as a function of schedule value. On a DRL 9-sec schedule of water reinforcement, imipramine at doses of 2.5 to 20.0 mg/kg resulted in no significant change in the number of reinforcements or responses. A dose of 5.0 mg/kg imipramine, given to rats performing on a DRL > 72-sec schedule, produced a significant increase in the number of reinforcements and a concomittant decrease in responses. This effect was associated with a shift in the inter-response time (IRT) distribution to longer IRTs. Higher doses (20.0 and 40.0 mg/kg) decreased both response rate and reinforcement rate on the DRL 72-sec schedule. These findings demonstrate the importance of schedule parameters in determining the behavioral effects of imipramine.
    [Abstract] [Full Text] [Related] [New Search]