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  • Title: N-(Phosphonacetyl)-L-aspartate (PALA): current status.
    Author: Rozencweig M, Abele R, Piccart M, Von Hoff DD, Muggia FM.
    Journal: Recent Results Cancer Res; 1980; 74():72-7. PubMed ID: 7444151.
    Abstract:
    N-(Phosphonoacetyl)-L-aspartate (PALA) is a synthetic antimetabolite exhibiting striking oncolytic properties against a wide variety of experimental solid tumors. The clinical dose-limiting factor is mucocutaneous toxicity which is reversible and dose-related. Delineation of the single-agent activity of PALA in human cancer must still await results of recently activated trials.
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