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  • Title: Incorporation of 14C-mevalonate into biliary cholesterol and bile acids by perfused rat liver: effect of plasma and individual lipoproteins.
    Author: Subbiah MT.
    Journal: Steroids; 1980 Oct; 36(4):497-505. PubMed ID: 7444999.
    Abstract:
    Effect of plasma and individual lipoproteins on the incorporation of 14C-mevalonate into biliary bile acids and cholesterol by perfused rat liver was investigated. Use of plasma free perfusate (instead of whole blood) gave similar rates of incorporation of 14C-mevalonate into biliary bile acids, but showed a decrease in percent distribution in cholic acid and a increase in beta-muricholic acid. Addition of VLDL (isolated from Zucker rats) into the plasma free perfusate caused a significant increase in the incorporation of the label into bile acids, but LDL and HDL had no effect. HDL caused an increase in biliary excretion of 14C-cholesterol.
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