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  • Title: Limitations of Culling PATS/KOH/PAS method of differential diagnosis of metastatic colorectal cancer.
    Author: Stachura J, Skrzatek B, Urban A.
    Journal: Folia Histochem Cytochem (Krakow); 1978; 16(4):299-305. PubMed ID: 744535.
    Abstract:
    Investigations of Culling et al. showed the possibility of using KOH/PAS effect (visualisation of C7 and C8O-acylated sialic acids characteristic to colon mucin) for differential diagnosis of metastatic colorectal cancer. Our investigations revealed, however, KOH/PAS positive mucin prevailing in some cases of gallbladder, pancreatic and gastric cancer. This makes serious limitation of Culling method in the routine diagnostic work.
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