These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Acetylcholine metabolism in rat cerebral cortex after joint and separate administration of gamma-aminobutyric acid and bicuculline.
    Author: Kleinrok A, Tomaszewski A, Zaczkiewicz A, Kedziora E, Górny D, Billewicz-Stankiewicz J.
    Journal: Acta Physiol Pol; 1980; 31(3):225-31. PubMed ID: 7446141.
    Abstract:
    Bicuculline (BK) administered into the lateral ventricle (i.v.c.) of Wistar rats in a dose of 10 microgram reduced the level and the intensity of acetylcholine (ACh) synthesis in rat brain cortex. On the other hand, Bk administered in the same way in doses of 1, 5 and 10 microgram decreased the activity of acetylcholine esterase. Gamma-aminobutyric acid (GABA) administered i.v.c. in a dose of 600 microgram increased the level and synthesis of ACh and the activity of choline acetyltransferase in rat cortex. The effects of GABA were abolished, however, by pretreatment with Bk.
    [Abstract] [Full Text] [Related] [New Search]