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  • Title: Antiesterase activity of chlorphenvinphos and phospholine in certain rat tissues after administration by different routes.
    Author: Kisieliński T, Gajewski D, Gidyńska T, Owczarczyk H.
    Journal: Acta Physiol Pol; 1980; 31(3):279-88. PubMed ID: 7446144.
    Abstract:
    The reported investigations were carried out on female Wistar rats receiving chlorphenvinphos and phospholine in doses equalling 3/4 LD50 onto the skin and intragastrically. the levels of acetylcholinesterase (AChE) were determined in the erythrocytes, liver and tibialis muscle and in three brain areas: pontomedullary area, hypothalamus and cerebral cortex. The activity of the enzyme was determined 15 and 30 minutes, and 3, 24 and 72 hours after poisoning. A high degree of AChE inhibition was observed in the brain after chlorphenvinphos poisoning (activity fall to 15--30%) and a slight decrease of AChE activity after administration of phospholine independently of the route. After oral poisoning with both preparations the AChE activity level in the erythrocytes was from about 27% to 31%, in the liver from 18 to 23%, and in the skeletal muscle from 51 to 54%, while with the transcutaneous route of poisoning these values were: 18--23%, 41--52%, and 36--48% respectively. A high degree of enzyme restoration was observed during 72 hours of observation. AChE activity was then 60--80% of the initial value.
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