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  • Title: Positive inotropic effects of hydralazine in human subjects: comparison with prazosin in the setting of congestive heart failure.
    Author: Leier CV, Desch CE, Magorien RD, Triffon DW, Unverferth DV, Boudoulas H, Lewis RP.
    Journal: Am J Cardiol; 1980 Dec 01; 46(6):1039-44. PubMed ID: 7446418.
    Abstract:
    Hydralazine possesses positive inotropic properties in animal model preparations. To determine whether this vasodilator elicits a positive inotropic response in the failing human ventricle, hydralazine, 75 or 100 mg, was administered orally to 14 patients with left ventricular dysfunction and congestive heart failure; the results were compared with those of first-dose prazosin at 5 and 10 mg. The duration of the preejection period and the isovolumic developed pressure/duration of isovolumic contraction (delta P/delta t) were used as indexes of inotropy. Prazosin did not effect a significant response in the duration of the preejection period or in the delta P/delta t. Hydralazine significantly shortened the preejection period and increased the delta P/delta t over 8 hours after administration; these data suggest that hydralazine elicits a positive inotropic response in the failing human ventricle.
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