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  • Title: Malabsorption and gastric hyperacidity in systemic mastocytosis. Results of cimetidine therapy.
    Author: Bredfeldt JE, O'Laughlin JC, Durham JB, Blessing LD.
    Journal: Am J Gastroenterol; 1980 Aug; 74(2):133-7. PubMed ID: 7446515.
    Abstract:
    Visceral infiltration by mast cells (systemic mastocytosis) is an unusual manifestation of cutaneous mastocytosis. Symptomatic gastrointestinal disease occurs in approximately one-fourth of patients having systemic mastocytosis. An unusual gastrointestinal complication is malabsorption, described in sporadic case reports. A patient with gastric acid hypersecretion and malabsorption is described. Treatment using the histamine H2 antagonist, cimetidine, ameliorated the patient's gastrointestinal symptoms; however, the malabsorption was not resolved.
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