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  • Title: Schistosoma mansoni: comparison of the killing effect of granulocytes and complement with or without antibody on fresh and cultured schistosomula in vitro.
    Author: Novato-Silva E, Nogueira-Machado JA, Gazzinelli G.
    Journal: Am J Trop Med Hyg; 1980 Nov; 29(6):1263-7. PubMed ID: 7446818.
    Abstract:
    The efficiency of human granulocytes from patients infected with Schistosoma mansoni in killing either 2-hour or 24-hour schistosomula in the presence of complement was 43.0 +/- 5.0% and 22.7 +/- 1.8%, respectively. Granulocyte, antibody, and complement killed 61.1 +/- 1.7% of 2-hour schistosomula and 13.9 +/- 1.9% of schistosomula previously incubated for 24 hours in complex medium. The resistance of 24-hour schistosomula was less marked when they were incubated in defined medium (20.0 +/- 1.5%). When the 24-hour incubation was performed in the presence of puromycin, however, the death of schistosomula remained high: 51.9 +/- 5.7% with cells plus complement or 48.7 +/- 4.8% with cells, antibody, and complement. The increase in eosinophil percentage in granulocyte suspensions did not enhance their ability to kill 24-hour schistosomula, but it was associated with a slight increase in the degree of damage inflicted on the 2-hour schistosomula.
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