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  • Title: Massive intravenous bolus bretylium tosylate.
    Author: Bodnar T, Nowak R, Tomlanovich MC.
    Journal: Ann Emerg Med; 1980 Dec; 9(12):630-3. PubMed ID: 7447102.
    Abstract:
    A 30 mg/kg (2-gm) intravenous bolus of bretylium tosylate was administered to a patient with recurrent ventricular tachycardia and fibrillation. After successful defibrillation the patient exhibited marked hypertension followed by protracted refractory hypotension. There was no further ventricular ectopy in spite of a very low cardiac index. A bretylium level of 8,800 ng/ml is the highest reported in man from a single bolus injection. This case demonstrates the exaggerated hemodynamic response to massive intravenous bolus bretylium tosylate.
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