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  • Title: Comparative nephrotoxicities of high-dose netilmicin and tobramycin in rats.
    Author: Parker RA, Gilbert DN, Houghton DC, Porter GA, Bennett WM.
    Journal: Antimicrob Agents Chemother; 1980 Aug; 18(2):346-8. PubMed ID: 7447411.
    Abstract:
    The nephrotoxic potentials of netilmicin and tobramycin given in doses of 180 mg/kg per day for up to 14 days were compared in Fischer rats. At this dosage, tobramycin produced mortality and significant changes in renal structure and function; netilmicin evoked minimal nephrotoxicity.
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