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  • Title: [Redox and phosphorylation equilibrium of the central metabolic pathway: rat liver profile in controls and after treatment with dichloroacetate and phenformin following dichloroacetate].
    Author: Cingolani ML, Bastianelli P, Cannelli B, Salvucci MP.
    Journal: Boll Soc Ital Biol Sper; 1980 May 30; 56(10):1097-102. PubMed ID: 7448013.
    Abstract:
    Glycolytic-, oxidative shunt, and mitochondrial metabolites, UDPG and high-energy-phosphates were measured in the liver of rats treated with Phenformin and/or Sodium Dichloroacetate. The substrate level profiles of the acute (90-60 min before sacrifice) treated groups were studied, and the interrelationships among substrate-coupled pyridine dependent dehydrogenase-redox potentials, the high energy-potentials of cytosolic and mitochondrial spaces, in the above-mentioned conditions, are discussed.
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