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  • Title: Chronic hemolytic anemia due to a monoclonal IgG cold agglutinin with anti-Pr specificity.
    Author: Dellagi K, Brouet JC, Schenmetzler C, Praloran V.
    Journal: Blood; 1981 Jan; 57(1):189-91. PubMed ID: 7448411.
    Abstract:
    Immunologic studies performed in a case of autoimmune chronic hemolytic anemia with low titer cold agglutinins (1/16) demonstrated that the cold agglutinins corresponded to monoclonal IgG with anti-Pr specificity. This antibody had a large thermal amplitude, being active at 37 degrees C. These unusual characteristics may define a distinct subset of chronic cold agglutinin disease.
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