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  • Title: In vitro induction of ornithine decarboxylase in urinary bladder carcinoma cells.
    Author: Izumi K, Hirao Y, Hopp L, Oyasu R.
    Journal: Cancer Res; 1981 Feb; 41(2):405-9. PubMed ID: 7448785.
    Abstract:
    The induction of ornithine decarboxylase by normal rat urine in bladder cancer cell cultures was tested in view of recent observations that urine acts as a tumor promoter. Addition of urine up to 15% in final concentration to culture medium resulted in a 10-fold increase in ornithine decarboxylase activity over the control. The stimulatory factor(s) contained in urine appears heat stable and may be multiple. 12-O-Tetradecanoylphorbol-13-acetate, a potent promoter in mouse skin carcinogenesis, induced a 39-fold increase in ornithine decarboxylase activity, the best response among the various substances tested. This suggests that it may act as a promoter of bladder cancer.
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