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  • Title: Glycine enhancement of caudate neuronal activities: relationship with the dopaminergic nigrostriatal pathway.
    Author: Finnerty EP, Chan SH.
    Journal: Eur J Pharmacol; 1980 Oct 31; 67(4):477-9. PubMed ID: 7449827.
    Abstract:
    Glycine microinjection into the substantia nigra zona compacta (SNC) in lightly anesthetized rats produced a marked and rapid decrease in spontaneous discharges of SNC neurons and a simultaneous enhancement of caudate nucleus (CN) activities. In animals pretreated with the dopamine receptor blocker, haloperidol, intranigral microinjection of glycine produced a dissociation of the nigral inhibition and caudate excitation. The SNC neurons were similarly suppressed while the CN neurons exhibited no discernible change in firing frequency. A possible role was suggested for glycine as an inhibitory neurotransmitter acting on the cells of origin of the nigrostriatal pathway.
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