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  • Title: [Effect of nonachlazine on ino- and chronotropic function].
    Author: Rozonov IuB, Chumburidze VB.
    Journal: Farmakol Toksikol; 1980; 43(5):575-9. PubMed ID: 7449987.
    Abstract:
    As a result of the stimulation of beta-adrenostructures of the myocardium nonachlazin intensifies ino- and chronotropic functions of the heart. This effect does not manifest after administration of practolol and is less pronounced in animals anesthesized with urethane and alpha-chloralose since the sensitivity of the beta-adrenostructures of the myocardium decreases under the influence of the anesthetics. Apart from the stimulation of ino- and chronotropic function of the heart nonachlazin reduces concurrently the intensity of positive chronotropic effect of isoproterenol. Such a combination of the efects called a "partial" beta-adrenoblockade seems likely to play an important role in the manifestation of the antianginal action of nonachlazin.
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