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  • Title: [Study of some derivatives of the benzotriazole nucleus].
    Author: Calvino R, Mortarini V, Serafino A.
    Journal: Farmaco Sci; 1980 Mar; 35(3):240-7. PubMed ID: 7450029.
    Abstract:
    The syntheses of 1-(beta-dimethylaminoethoxy)benzotriazole, 1-(gamma-dimethylaminopropoxy)benzotriazole and of their N-oxide isomers 3-(beta-dimethylaminoethyl)benzotriazole 1-oxide and 3-(gamma-dimethylaminopropyl)benzotriazole 1-oxide are reported. The structure of these compounds has been confirmed by N.M.R. spectroscopy; the structures of the N-oxide derivatives was also elucidated by chemical reduction to the parent benzotriazoles. The two benzotriazoles were also tested for antiinflammatory activity in the rat, and for analgesic and depressant activity on the CNS of the mouse.
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