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  • Title: Derivatives of 5,7,7-trimethyl-6-oxa-3-azabicyclo[3.2.2]nonane with antiarrhythmic, local anesthetic and hypotensive activities. I.
    Author: Bondavalli F, Schenone P, Lanteri S, Longobardi M, Rossi F, Rosatti F, Ottavo R, Marmo E.
    Journal: Farmaco Sci; 1980 May; 35(5):380-93. PubMed ID: 7450037.
    Abstract:
    The synthesis of three series of 3-acyl-, 3-alkyl- and 3-dialkylaminoacetyl-5,7,7-trimethyl-6-oxa-3-azabicyclo[3.2.2]nonanes, (III), (IV) and (V), respectively, is described. A number of these compounds showed surface anesthesia in rabbits and infiltration anesthesia in mice, and antiarrhythmic activity in guinea pigs and mice, all effects being superior or similar to those of lidocaine. The circulatory, cardiac and respiratory effects in dogs and hens are also described.
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