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  • Title: Synthesis and analgesic activity of N-substituted 6,7-benzomorphans.
    Author: Bellora E, Cereda E, Ezhaya A, Marazzij-Uberti E, Pala G, Donetti A.
    Journal: Farmaco Sci; 1980 Jun; 35(6):490-7. PubMed ID: 7450042.
    Abstract:
    Some new N-substituted 6,7-benzomorphans were prepared and tested for analgetic activity. The compounds (I) and (II), which proved the most active in a preliminary screening, were submitted to a more detailed investigation, and their ED50 was determined in mice by the phenylquinone, hot-plate and tail-pinch tests. Studies of acute toxicity and physical dependence capacity were also performed.
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