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  • Title: Endometrial biopsy during a cycle of conception.
    Author: Sulewski JM, Ward SP, McGaffic W.
    Journal: Fertil Steril; 1980 Dec; 34(6):548-51. PubMed ID: 7450073.
    Abstract:
    Endometrial biopsies obtained from 18 infertile women during early intrauterine pregnancy were examined histologically. The cycle date on which the biopsies were obtained was determined from the day of ovulation by basal body temperature charts and prior menstrual history. The average cycle dates of the biopsies were similar for the women who delivered at term or who had first-trimester spontaneous abortions. Among the women who delivered at term, the average histologic date assigned to the specimens was significantly earlier than the average cycle date. In contrast, among the women who had early pregnancy loss, the specimens had an average histologic date significantly later than the average cycle date. A histologic date of later than 25 days or later than the cycle date of the biopsy was associated with a poor prognosis for the pregnancy. 18 infertile women from the Milton S. Hershey Medical Center in Pennsylvania underwent endometrial biopsy during the cycle of conception. The endometrial biopsies were examined histologically and dated by 4 different examiners within 2-day interval rates. Average cycle date on which biopsies were obtained was day 25 (range 21 to 28). 13 of the 18 women delivered at term, 4 had histologically documented 1st-trimester spontaneous abortions, and 1 was lost to follow up in the 2nd trimester. Pregnancy outcome did not correlate with day of cycle on which biopsy was taken. Overall incidence of obtaining endometrial biopsy during the cycle of conception in this group of patients was 6.2%, an incidence similar to that by Wentz but greater than that observed by others (0.05% to 4.2%). Average histologic date assigned to specimens was earlier than the average cycle date on which the biopsy was taken. Pregnancy outcome correlated with the histologic dates of the endometrium, with the number of 1st trimester abortion significantly increased among those whose endometrium was dated histologically later than the cycle date of biopsy or later than day 25.
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