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  • Title: Demonstration of IgG-Fc and C3 receptors on adult Schistosoma mansoni.
    Author: Tarleton RL, Kemp WM.
    Journal: J Immunol; 1981 Jan; 126(1):379-84. PubMed ID: 7451978.
    Abstract:
    Previous studies have indicated that adult schistosomes have an affinity for both IgG and C; however, thorough investigations on the possible presence of receptors for these serum proteins on the adult schistosome tegument have not been attempted. The present study presents evidence for both IgG-Fc and C3 receptors on adult schistosomes. An indirect assay utilizing fluoresceinated Staphylococcus aureus was developed to detect antigen-antibody (Ag-Ab) and antigen-antibody-C (Ag-Ab-C) binding to adult parasites. Detection of Ag-Ab and Ag-Ab-C complex binding was dependent on the presence of a metabolic inhibitor in the incubation mixture presumably to prevent shedding of bound complexes. Ag-Ab complex binding required the presence of an intact Fc on the IgG of the complex and could be partially inhibited by preincubation of parasites in heat-aggregated IgG or an isolated Fc preparation. Binding of Ag-Ab-C complexes was dependent on active C3 in the C source but not on an intact Fc on the IgG of the complex. Ag-Ab-C binding could be blocked by prior incubation of parasites in heat-aggregated IgG-C but not by C alone. Binding of host serum proteins to IgG-Fc and C3 receptors on adult schistosomes may aid parasite survival by helping to prevent immune detection.
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