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  • Title: On the regulation of acetylcholine release: a study utilizing Torpedo synaptosomes and synaptic vesicles.
    Author: Michaelson DM, Avissar S, Ophir I, Pinchasi I, Angel I, Kloog Y, Sokolovsky M.
    Journal: J Physiol (Paris); 1980 Sep; 76(5):505-14. PubMed ID: 7452519.
    Abstract:
    1. Addition of ATP to isolated highly purified Torpedo synaptic vesicles results in 45Ca2+ uptake. 2. Ca2+ dependent ACh release from Torpedo synaptosomes is accompanied by the phosphorylation of a specific protein with an apparent subunit molecular weight of about 100,000 (band alpha). 3. Activation of the presynaptic muscarinic receptors by an agonist inhibits Ca2+-dependent ACh release from Torpedo synaptosomes. This process seems to be mediated through an interference with the phosphorylation of the band alpha protein, and not by blocking the voltage-dependent presynaptic Ca2+ channel.
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