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  • Title: Chemotherapy against human melanoma in the hamster cheek pouch.
    Author: Dufour FD, Okada GT, Mah SG, Morton DL.
    Journal: J Surg Oncol; 1980; 15(4):355-61. PubMed ID: 7453185.
    Abstract:
    Human malignant melanoma was transplanted to the cheek pouch of immunosuppressed (corticosteroid-treated) hamsters. Significant differences were observed in tumor growth constants for animals treated with methotrexate, DTIC, BCNU, and vincristine (P < 0.05) compared to controls. However, no appreciable effect was demonstrated for Adriamycin, 5-FU, and cytoxan. In addition, single doses as high as 400 mg/kg body weight of methotrexate were no more effective than other agents now used against this neoplasm.
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