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  • Title: [Effects of an intravenous bolus of althesin on intracranial pressure and related functions].
    Author: Zattoni J, Siani C, Guardincerri C, Rossi A.
    Journal: Minerva Anestesiol; 1980 Feb; 46(2):193-8. PubMed ID: 7453984.
    Abstract:
    30-40 min after i.m. administration of 0.5 mg atropine sulphate, 8 adult conscious neurosurgical patients on spontaneous ventilation were given a total of 10 rapid i.v. injections of Althesin at a dosage of 40-50 (45.5 +/- 4.33 as a mean) microliter/kg. Method was able to induce clinical and EEG signs of deep anaesthesia. PICm and PAm decreased in all cases by 6.82 +/- 3.91 (P < 0,05) and 20.18 +/- 9.30 mmHg respectively; PVCm decreased in only half of the cases. The intracranial hypotensive effect was positively correlated to the basal PICm (P < 0.05) and resulted proportionately more marked in cases with greater signs of EEG depression. The PAm never decreased below 60 mmHg. The paCO2 was generally increased and the paO2 was always decreased. The intracranial hypotensive effects regressed 12-23 min after the injection without dangerous rebound effects; recovery of the PAm was slower. The use of Althesin in the anaesthesia and in the intensive care of neurosurgical patients is discussed.
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