These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


PUBMED FOR HANDHELDS

Search MEDLINE/PubMed


  • Title: Kidney disease.
    Author: Mihatsch MJ, Zollinger HU.
    Journal: Pathol Res Pract; 1980 May; 167(1):88-117. PubMed ID: 7454603.
    Abstract:
    The diagnostic highlights under electron microscopy in hereditary nephropathies and glomerulonephritides are reviewed: Alport's syndrome--lamellation, fragmentation and reticulation of glomerular basement membrane; benign essential (familial) hematuria--glomerular basement membrane thinning; nail patella syndrome--moth eaten holes and collagen like fibrils in glomeruli; nephronophthisis--thickening, thinning, reticulation and loss of tubular basement membrane; intramembranous and epimembranous glomerulonephritis--unequivocal diagnosis in early and late stages; extracapillary glomerulonephritis--exact classification of the basic type of glomerulonephritis; segmental focal sclerosing glomerulonephritis--unequivocal diagnosis of early stages and differentiation from other forms of glomerulonephritis or other nephropathies; Schönlein-Henoch's syndrome--scanty subepithelial deposits encases by a thin lamella of lamina densa; SLE--deciphering mixed forms of glomerulonephritis and demonstration of virus-like tubular structures in endothelium, so-called organized deposits, interstitial immunocomplex nephritis; mixed IgG/IgM cryoglobulinaemia--crystalloid structure of deposits; IgA nephritis--unequivocal demonstration of mesangial deposits; congenital nephrotic syndrome--irregularity of glomerular basement membrane and finally amyloidosis--unequivocal diagnosis. It is concluded that electron microscopy contributes information of clinical relevance in 30% of cases. Thus, electron microscopy should be used (in addition to light microscopy and immunofluorescence), whenever a renal biopsy specimen is to be critically evaluated.
    [Abstract] [Full Text] [Related] [New Search]