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  • Title: [Effect of lysosomal cathepsin D and acid phosphatase on collagen protein catabolism in cirrhotically altered liver after stimulating regeneration with choriogonin].
    Author: Blinova TV, Kosykh AA, Solopaeva IM.
    Journal: Vopr Med Khim; 1980; 26(3):410-5. PubMed ID: 7456375.
    Abstract:
    Dependence of collagen fractions content from the activities of cathepsin D and acid phosphatase as well as dynamics of their alteration under the influence of choriogonine were studied in cirrhotic liver tissue of rats. Content of the collagen proteins was decreased, with simultaneous increase in amount of their soluble fractions, after treatment of the animals by choriogonine. At the first step of the experiment the activity of the hydrolytic enzymes was decreased but it was normalized to the end of the experiment; at the same time, activity of cathepsin D remained high in the non-sedimentable fraction. Correlation between the activity of cathepsin D and content of collagen fractions was observed in the liver tissue. This enzyme appears to participate in catabolism of collagen.
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