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  • Title: [Different effects of kynurenines on rat liver tryptophan pyrrolase activity].
    Author: Kiseleva IP, Lapin IP, Prakh'e IB, Samsonova ML.
    Journal: Vopr Med Khim; 1980; 26(4):458-61. PubMed ID: 7456383.
    Abstract:
    3-Hydroxyanthranilic, quinolinic and nicotinic acids/50 mg/kg, intraperitoneally/increased the content of rat blood plasma 11-hydroxycorticosteroids as well as the activity of liver tryptophane pyrrolase. After administration of anthranili and picolinic acids, elevation in 11-hydroxycorticosteroid content was not followed by an increase in the tryptophane pyrrolase activity. Picolinic acid diminished induction of tryptophane pyrrolase activity by hydroxycortisone and anthranilic acid dicc not affect the induction. Adrenalectomy prevented the increase in tryptophane pyrrolase activity after treatment with nicotinic, quinolinic and 3-hydroxyanthranilic acids. Prolonged augmentation of kynurenines in the organism might be a result of a mediated through corticosteroids increase in the tryptophane pyrrolase activity caused by elevation in the level of 3-hydroxyanthranilic, quinolinic and nicotinic acids.
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