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  • Title: [Changes in oxidative phosphorylation in rat liver mitochondria during the development of cholestasis].
    Author: Konstantinov IuM, Filippova SN, Vavilin VA, Panov AV, Liakhovich VV.
    Journal: Vopr Med Khim; 1980; 26(4):498-502. PubMed ID: 7456389.
    Abstract:
    Kinetic patterns of oxydative phosphorylation were studied in rat liver mitochondria in dynamics of cholestasis and after addition of bile acids to mitochondria in vitro. Within the 1 and 3 days of cholestasis mitochondrial synthesis of ATP was decreased due to inhibition of ATP and ADP transport by the bile acids. At the period within 3 and 15 days uncoupling of the oxidative phosphorylation occurred; the phenomenon observed might be a result of impairment in the structure of inner mitochondrial membrane.
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