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  • Title: [Effect of acrylonitrile on gamma-aminobutyric acid levels, glutamate decarboxylase activity, and lipid peroxidation in rat brain].
    Author: Al'shanskiĭ AM, Ivanov VV, Promyslov MSh.
    Journal: Vopr Med Khim; 1980; 26(4):507-9. PubMed ID: 7456391.
    Abstract:
    Acrylonitrile after intraperitoneal administration into rats decreased the content of gamma-aminobutyric (GABA) and inhibited the glutamate decarboxylase activity in brain tissue. Incubation of brain supernatant with acrylonitrile led to stimulation of lipid peroxidation and to a decrease in content of thiols, alpha-Tocopherol prevented the prooxidant effect of acrylonitrile in vitro as well as its effect on glutamate decarboxylase activity and on GABA content in vivo. The neurotoxic effect of acrylonitrile might be related to stimulation of lipid peroxidation.
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