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  • Title: Antioxidants as agents reducing the toxicity of indomethacin.
    Author: Krupińska J, Sobański H, Piotrowicz J, Cebo B, Mazur J.
    Journal: Acta Biol Med Ger; 1980; 39(6):717-21. PubMed ID: 7456934.
    Abstract:
    Simulataneous oral administration of butylhydroxytoluene (BHT) (50 or 100 mg/kg) with indomethacin (IND) (3, 6 or 20 mg/kg) prevented the damaging effect of IND on the rat gastric mucosa. Butylhydroxyanisole (BHA) and nordihydroguiaretic acid (NDGA) rather potentiated than prevented the noxious action of IND. A reduction of IND toxicity without affecting its anti-inflammatory action seems to be possible to achieve by concomitant administration of IND with BHT.
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