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  • Title: [Evolution of hepatic periovular granulomas in different types of repeated infections with S. mansoni in mice (author's transl)].
    Author: Abouzkham AA, Buttner A.
    Journal: Ann Parasitol Hum Comp; 1980; 55(2):199-207. PubMed ID: 7458158.
    Abstract:
    Effects upon hepatic granulomas in Swiss albino mice after challenged exposures to S. mansoni are studied: the time between the previous and the challenged infections had a major influence on the number, size and histological features of granulomas in residual infections; 15 days delay has not stimulated any protection against the challenge which developed freely, while 6 months delay impeded the 2nd infection which was abortive. However, in spite of a 6 months delay observance, no stimulation of protective immunity was obtained when the level of the primary infection was of 50 cercariae, while this protection became effective when the rate of primo-infection reached 100 or 200 cercariae. Opinions differ on the part of primo-infection in the induction of a protective immunity. It seems that the rate of efficiency of primo-infection depends on the mean level of antigenicity of the infective cercariae.
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