These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Cytotoxic and cytokinetic effects of 1-beta-D-arabinofuranosylcytosine, daunorubicin, and 6-thioguanine on HeLa cells in culture.
    Author: Fried J, Perez AG, Doblin JM, Clarkson BD.
    Journal: Cancer Res; 1981 Mar; 41(3):1127-32. PubMed ID: 7459856.
    Abstract:
    Exponentially growing HeLa cells were exposed to 1-beta-D-arabinofuranosylcytosine, daunorubicin, and 6-thioguanine singly and in combination for 21 hr. Survivals were determined by a colony-counting assay, and cytokinetic effects of the drugs were evaluated by flow cytometry. When used in two-drug combinations (concurrent exposures). 1-beta-D-arabinofuranosylcytosine was found to protect cells against both 6-thioguanine- and daunorubicin-induced lethality, the former to a greater extent than the latter. Protection against 6-thioguanine appeared to be related to the degree of inhibition of DNA synthesis by 1-beta-D-arabinofuranosylcytosine, but this was not the case with daunorubicin. When cells were exposed to the three drugs simultaneously, survivals were in agreement with those predicted from the various two-drug combinations. This implies that no additional drug interactions occurred when a third drug was added to the two-drug combinations.
    [Abstract] [Full Text] [Related] [New Search]