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  • Title: Radionuclide imaging of experimental myocarditis.
    Author: Reeves WC, Jackson GL, Flickinger FW, Kwee HG, Schwiter EJ, Werner J, Whitesell L, Biddle MA, Copenhaver G, Shaikh BS, Zelis R.
    Journal: Circulation; 1981 Mar; 63(3):640-4. PubMed ID: 7460250.
    Abstract:
    The ability of 67Ga citrate and 99mTc pyrophosphate cardiac imaging to detect myocarditis was assessed in an experimental rabbit model. Twenty-three rabbits were imaged approximately 72 hours after infusion of i.v. norepinephrine. Diffuse cardiac uptake was found in 13 of 15 rabbits scanned with 67Ga. Tissue distribution studies documented significant myocardial uptake of 67Ga in those with positive scans. Precordial imaging and tissue distribution studies revealed no cardiac uptake in the eight rabbits scanned with 99mTc. Histologic examination of all 23 hearts revealed qualitatively similar, typical lesions of myocarditis. This study suggests that cardiac imaging with 67Ga may be useful in the detection of myocarditis.
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