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  • Title: Effect of pyran copolymer on murine hemopoiesis.
    Author: Zander AR, Spitzer G, Verma DS, Beran M, Dicke KA.
    Journal: Exp Hematol; 1980 May; 8(5):521-6. PubMed ID: 7461054.
    Abstract:
    Pyran Copolymer (NSC-46015), a divinyl-ether maleic anhydride leads to a significant shift in distribution of nucleated cells and CFUs in the bone marrow and spleen. The bone marrow cellularity and the CFUs content reach a nadir 4 to 6 days after Pyran injection, simultaneous rise in spleen cellularity and CFUs concentration of circulating pluripotent stem cells by a factor of 10 to 45 and a concomitant rise of CFUc is seen. the origin of the mobilized pluripotent stem cells is likely to be the bone marrow, not athe spleen.
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