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  • Title: Plasma erythropoietin levels in fetal and newborn rats: response to hypoxia.
    Author: Meberg A.
    Journal: Exp Hematol; 1980 May; 8(5):615-9. PubMed ID: 7461059.
    Abstract:
    Plasma erythropoietin (Ep) activity was detectable in fetal rats near term and in rats less than 2 old. Ep activity was not found 12--48 h after birth. A hypoxic period (0.5 atmospheres for 6 h) increased the plasma Ep level in fetal and newborn rats, and in pregnant animals. After long-term hypoxia (0.5 atmospheres for 8 days) the plasma Ep level was neither increased in fetal rats nor in their mothers, while a compensatory increase in the hematocrit level occurred. It is concluded that hypoxia stimulates Ep production during hepatic erythropoiesis. During long-term hypoxia compensatory mechanisms for tissue oxygenation occur.
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