These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Evaluation of K-canrenoate in post-surgical treatment of open heart paediatric surgery (author's transl)].
    Author: Capuani A, Bernabei M, Pasque A, Eufrate S.
    Journal: G Ital Cardiol; 1980; 10(9):1148-55. PubMed ID: 7461364.
    Abstract:
    The variation of Aldosterone and its consequences on urinary Sodium and Potassium after cardiac surgical trauma are well known. We made a study on 2- pediatric patients operated by extracorporeal circulation (ECC). Ten patients were given an Aldosterone inhibitor (K-canrenoate), ten patients were the control group. The efficacy of treatment with the Aldosterone inhibitor drug is proved by: 1) progressive, significant drop of Natremia; 2) considerable heightening of Kaliemia; 3) significant higher ratio between Natriuria and Kaliuria. The importance of antialdosteronic treatment is demonstrated by: 1) diminished sodium retention implies a lessened water retention; 2) increased potassium retention protects from dangerous hypokaliemia in the early postoperative period; 3) possible inotropic and extrarenal activity. It's important to modify the dose of K-canrenoate in relation to the level of electrolytes. High levels of potassium may follow a dosage of 2,5 mg/Kg/24 h. In other cases higher dosage may be necessary.
    [Abstract] [Full Text] [Related] [New Search]