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  • Title: Synthesis of [8-alpha-hydroxyisocaproic acid]oxytocin. Biological activities and comparison of its in vivo uterine actions to those of deamino-[8-alpha-hydroxyisocaproic acid]oxytocin, deamino-oxytocin and oxytocin.
    Author: Roy J, Gazis D, Schwartz IL.
    Journal: Int J Pept Protein Res; 1980 Aug; 16(2):106-10. PubMed ID: 7461893.
    Abstract:
    The synthesis and biological activities of [8-alpha-hydroxyisocaproic acid]oxytocin are reported. The in vivo uterine responses to [8-alpha-hydroxyisocaproic acid] oxytocin are prolonged and those to deamino-[8-alpha hydroxyisocaproic acid] oxytocin (as well as those we have previously reported for deamino-oxytocin) are very prolonged as compared with those of oxytocin. Time courses of the in vivo uterine responses to deamino-[8-alpha-hydroxyisocaproic acid]oxytocin and deamino-oxytocin (as followed by plotting the intervals between the individual contractions of a response vs. time after peptide injection) differ from those to [8-alpha-hydroxyisocaproic acid]oxytocin and oxytocin.
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