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  • Title: Binding of cationized ferritin to the cell-coat glycoproteins of human and rat small-intestinal absorptive cells.
    Author: Blok J, Mulder-Stapel AA, Ginsel LA, Daems WT.
    Journal: Histochemistry; 1980; 69(2):131-5. PubMed ID: 7462007.
    Abstract:
    The binding of cationized ferritin (CF) to the cell-coat (glycocalyx) glycoproteins of human and rat intestinal absorptive cells was investigated in relation to the amount of sialic acid in these macromolecules. The cell coat of human absorptive cells exhibited poor binding of CF and contained a small amount of sialic acid. The cell coat of rat absorptive cells had about ten times more sialic acid than that of human cells and showed a strong affinity for the marker. The removal of sialic acid from the cell-coat glycoproteins of rat intestinal cells by neuraminidase treatment abolished CF binding. These results suggest that sialic acid is necessary for CF binding and that human and rat intestinal absorptive cells show a species-specific difference in the sugar composition of the cell coat.
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