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  • Title: Effect of fibrinogenolytic products D and E on fibrinogen and albumin synthesis in the rat.
    Author: Franks JJ, Kirsch RE, Frith LO, Purves LR, Franks WT, Franks JA, Mason P, Saunders SJ.
    Journal: J Clin Invest; 1981 Feb; 67(2):575-80. PubMed ID: 7462430.
    Abstract:
    Previous studies are in conflict over the effect of infusing mixed fibrinogen-fibrin degradation products on fibrinogen synthesis, as determined by changes in fibrinogen concentration or by incorporation of labeled amino acids into fibrinogen. We have injected purified homologous fragments D1 and E into rats and measured their fibrinogen and albumin synthetic rates by the [14C]carbonate technique, a method that provides quantitative estimates of hepatic secretory protein synthesis. Fibrinogen fractional synthetic rates were increased 2.5 times in animals injected with fragment D1, compared with saline-injected controls. No increase were observed in fragment E-injected animals. Neither fragment produced changes in albumin synthesis. Fragment D increased plasma fibrinogen concentration, but did not raise plasma haptoglobin levels. These results suggest that fragment D is a regulator of fibrinogen synthesis.
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